MH-BactoProtech ™

The tindalized probiotic approach represents an alternative strategy in the prevention and treatment of infectious diseases, not only at the intestinal level but also at other sites of the body where the microbiota plays a role in the maintenance of physiological homeostasis. 

Metis Healthcare has the exclusive license for MIMLh5 to prevent Streptococcus pyogenes infections at the pharyngeal level (pharyngitis).

MH-BactoProtech, based on Lactobacillum Helveticus MIMLH5, was studied by University of Milan in its action of competition with pathogens, reduction of inflammation, immunomodulation activity and reduction of symptoms of allergic reactions through the restoring of the Th1/Th2 balance.

Lactobacillum Helveticus MIMLH5, exerts its action even when inactivated (tyndalized), this improves user safety and make this bacteria allowable for use in medical devices according to current EU Regulation.

01 – Appl Environ Microbiol. 2012 Jun;78(12):4209-16. doi: 10.1128/AEM.00325-12. Epub  2012 Apr 13.
In vitro functional and immunomodulatory properties of the Lactobacillus helveticus MIMLh5-Streptococcus salivarius ST3 association that are relevant to the development of a pharyngeal probiotic product.
Taverniti V et al.

02 – Appl Environ Microbiol. 2019 Apr 18;85(9):e00138-19. doi: 10.1128/AEM.00138-19.  Print 2019 May 1.
Surface Layer of Lactobacillus helveticus MIMLh5 Promotes Endocytosis by Dendritic Cells
Taverniti V et al.

03 – Infect Immun. 2010 Nov;78(11):4734-43. doi: 10.1128/IAI.00559-10. Epub 2010 Aug 23.
A dairy bacterium displays in vitro probiotic properties for the pharyngeal mucosa by antagonizing group A streptococci and modulating the immune response. Guglielmetti S et al.

04 – Appl Environ Microbiol. 2014 Jan;80(2):694-703. doi: 10.1128/AEM.03057-13. Epub  2013 Nov 15.
Lactobacillus helveticus MIMLh5-specific antibodies for detection of S-layer protein in Grana Padano protected-designation-of-origin cheese. Stuknyte M et al.

05 – Appl Environ Microbiol. 2013 Feb;79(4):1221-31. doi: 10.1128/AEM.03056-12. Epub 2012 Dec 7.
S-layer protein mediates the stimulatory effect of Lactobacillus helveticus  MIMLh5 on innate immunity.
Taverniti V et al.

06 – Food Funct. 2017 Oct 18;8(10):3601-3609. doi: 10.1039/c7fo00829e.
In vitro assessment of the ability of probiotics, blueberry and food carbohydrates to prevent S. pyogenes adhesion on pharyngeal epithelium and modulate immune responses. Taverniti V et al.

07 – Otorinolaringologia 2020 June;70(2):38-42 DOI: 10.23736/S0392-6621.20.02269-9
Effects of paraprobiotic MIMLh5 in the treatment of chronic rhinopharyngitis Cavaliere C. Et al